| 背景 | BGLAP encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. Bone Gamma-Carboxyglutamate Protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1， but the encoded protein only shows sequence identity with the upstream gene product. |
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